The local branch of the RSPCA is urging the community to don an apron, whip out their wooden spoons and preheat their ovens to bake for a good cause.
The RSPCA's annual fundraiser Cupcake Day is on Monday August 19.
Port Macquarie RSPCA fundraising officer Carolyn Smith said all the funds would go towards animals in the region.
"All funds go towards helping treat neglected animals and providing care for animals in need in NSW," she said.
The cupcakes will be sold at Bunnings Port Macquarie from 9am until they sell out.
And while Cupcake Day is August 19 the public can bake cupcakes at any time during August and hold their own "cupcake event".
Miss Smith said the RSPCA was home to a whole range of animals.
"Chickens, roosters, dogs, cats, rabbits, we don't discriminate."
Miss Smith said the RSPCA received limited funding from the government and was staffed by volunteers.
"I worked as a midwife until I retired and now I devote all my time to saving animals," she said.
Miss Smith said her love of animals developed as a child.
She has a particular soft spot for greyhounds which have in the past been difficult to find a home for.
"They are great animals," she said.
"They don't really like exercise and they sleep most of the day, they are good with the elderly and they don't bark a lot or shed a lot.
"They are happy to live in apartments and are adaptable to family life."
More information on Cupcake Day is online.