An entangled whale trailing an orange/red buoy and lines could reach Port Macquarie by Tuesday afternoon or Wednesday.
Boat users and the wider community are being urged to keep watch for the mammal.
The cetaceans rescue group ORRCA says there has been some 29 reported sightings of entangled whales during this current migratory season.
ORRCA spokesperson Jools Farrell said the sighting and reporting of entangled whales and other marine life is important.
"Our whale population is increasing each year and that in turn means that there is the potential for more entanglements," she said.
"There is also quite a bit of fishing gear and nets out there as well.
"The problem for an entangled whale is that they get extremely tired, especially if they are trailing buoys and with ropes attached.
"It has been known that whales can manage to disentangle themselves. This was the case in two recent instances where the whales were able to free themselves," she said.
"But they need to be disentangled quickly."
Unfortunately, that quick action is completely weather dependent.
High winds and big seas make it extremely difficult for a rescue mission to be undertaken.
A dedicated National Parks and Wildlife Service crew is responsible for on-water rescues.
Whales do not know that we love them and if they are approached they could think there is an issue.Jools Farrell
Human safety is paramount and the prevailing conditions have to be good for the rescue team to attempt to head out to sea.
ORRCA has issued advice on what to do if you locate an entangled whale. Vessels are required to stay 300 metres from the mammal. If a NPWS rescue team is in situ, those vessels are required to be 500 metres away.
The public should not attempt to disentangle a whale themselves.
ORRCA also encourages people to take a photo of an entangled whale, get a direction the whale is travelling and a GPS location.
This information will aid ORRCA and NPWS in the rescue attempt.
"Whales do not know that we love them and if they are approached they could think there is an issue," Ms Farrell said.
With some 33,000 whales migrating each year, ORRCA says the number of entangled whales remains concerning.
"The message from us is to keep an eye out and if you do see an entangled whale, contact the ORRCA hotline and stay clear of the mammal."
Marine Rescue Port Macquarie's unit commander Greg Davies said any sightings can also be reported through the marine rescue service.
ORRCA is the only volunteer wildlife rehabilitation group in New South Wales licensed to be involved with marine mammal rescue, rehabilitation and release.
The ORRCA hotline is 9415 3333. For more information go their website.
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