It begins at the Avalon Airshow in Lara, Victoria, which is a 50 minute drive southwest of Melbourne.

From there a commemorative baton will be flown around the east coast of Victoria on to NSW and in an anti-clockwise direction until it arrives in Launceston on Aprill 22 in time for the start of the Australian Women Pilots' annual conference.

Seaplane pilot Judy Hodge will receive the baton from Kerry Nolan who will fly it up from Taree.

Ms Hodge joined the Women Pilots' Relay of Flight because her instructor Bill Lane survived cancer after an operation six years ago and she is "very glad he made it".

"He knows many of the pilots involved in the relay," she said.

"I am very lucky in my family no one has had cancer, but I lost a good friend my age who died of breast cancer."

Ms Hodge will fly the baton from Camden Haven Airfield in her Cessna 182 floatplane to Port Macquarie, keep it overnight, and then pass it on to the next pilot at Port Macquarie Airport the following day.

"Camden Haven is of particular relevance to the AWPA (Australian Women Pilots Association) with the main road of Kew named after [pioneering aviator] Nancy "Bird" Walton, [its founder and patron].

"She would have celebrated her 100th birthday [in October] this year."

The concept behind the flight relay is these women pilots wanted to help make a difference by sharing their love of flying.

Ms Hodge learned to fly in her homeland of South Africa in 1976.

"I wanted to become an airline pilot but my parents didn't think it was appropriate."

She attained her commercial pilot's licence at age 54 and five years ago bought her aircraft and spent the next two years lovingly restoring it.

"This is my dream come true. It's the love of my life. I know every little rivet, it's my baby."

Together the women pilots hope to raise $20,000, during what, so far, is a journey of 17,988 kilometres.

The pilots undertaking the journey fly aircraft including a Dash 8, a helicopter, a Boeing 737, a RAAF plane, a Qantas plane and more.

"Everyone is so friendly, it's wonderful," Ms Hodge said.

She hopes to encourage as many people to donate to the cause as possible by offering everyone who makes a donation the chance to enter a draw to join her on her leg of the relay flight.

It is hoped the fun-filled event will create a bit of history, support Cancer Council in its research for a cure for cancer and be a great journey.

Donations can be made at http://bit.ly/17wXaKC