Reynolds will leave his boyhood club after 10 seasons to join Brisbane at the end of the 2021 season.

First though, the 31-year-old believes he has the opportunity to claim a second grand final win with a South Sydney team which has fallen at the preliminary final stage in the past three seasons.

"It'd be the dream run to the end, obviously," Reynolds told AAP about his premiership ambition.

"They're certainly hard to win.

"I've been in a couple of prelims and fallen short and know how hard it is to get back there.

"We'll be doing everything possible to prepare the best we can and make sure we give it our best shot."

The Rabbitohs must do it all without star fullback Latrell Mitchell, whose season was ended by the lengthy suspension received for his high shot on Sydney Roosters centre Joseph Manu a fortnight ago.

Souths overcame St George Illawarra last weekend without Mitchell and Reynolds says the lack of the NSW State of Origin star hasn't plunged the playing group into despair.

"We've played four games without him this year, and we've won four," he said.

"Hopefully that trend continues.

"He's a big loss to our team, he's a vital member of the Rabbitohs but what's happened has happened and we've moved on."

The first hurdle in the Rabbitohs' path to a fairytale farewell for Reynolds is Penrith in Saturday's qualifying final in Townsville.

The Panthers gave Souths an almighty touch-up in May with a 56-12 drubbing in Dubbo but Reynolds believes the 25-12 loss to Penrith in late August is a much better indicator of the two teams' relative strengths and weaknesses.

"We've shown glimpses of how good we can be in games, it's just about doing that consistently for 80 minutes," he said.

"We pushed Penrith pretty well in that last game we played them and sort of fell away at that back end with that first half.

"In the second half they just capitalised on on our mistakes. If we can limit those mistakes and play our brand of football, we believe we can match it with them."

Australian Associated Press