A woman from the Mid North Coast in her 60s is the latest person to fall victim to COVID-19.

The woman is receiving care in Manning Hospital while the source of her infection continues to be investigated.

Two other Mid North Coast residents who returned from an overseas holiday have also tested positive but remain in isolation in Sydney.

This takes the total number of COVID-19 cases in the Hunter New England Health District (HNEH) to seven after a woman in her 40s also had contracted the illness.

The woman is in home isolation after recently returning for the US.

HNEH has reassured there is no connection between these two new cases.

The female in her 40s arrived in Sydney on American Airlines flight AA0073 from Los Angeles on March 11. NSW Health is asking anyone who travelled on this flight to be alert for fever or respiratory symptoms.

If they develop any of these symptoms, they should contact their GP or present to an emergency department.

HNEH is contacting close contacts of the two new cases, who also are being asked to self-isolate for 14 days from last contact.

They will be contacted every day to check that they are well and any contact who develops COVID-19 symptoms will be tested for the infection.

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