Mr Barilaro addressed the issue on Sky News on Wednesday night.

NSW One Nation leader Mr Latham's private member's bill is currently before the upper house and, if successful, would see the ban on uranium mining and nuclear lifted.

Labor leader Jodi McKay seized on Mr Barilaro's comments saying she had trouble taking the deputy leader seriously on nuclear power.

"Mr Barilaro and the nuclear industry have one thing in common: many of their promises never happen," she said.

NSW Labor also confirmed it would not introduce nuclear power in NSW, if elected.

Port Macquarie, Kempsey and Coffs Harbour have all been flagged as regions of interest for nuclear power plants.

MP Leslie Williams said The Nationals reaffirmed its commitment at last year's state party conference to support zero emission nuclear energy in Australia as part of the energy mix for the future.

"Following the Upper House inquiry into the mining of uranium in NSW and nuclear energy the process going forward is that the government will respond through the usual cabinet process and The Nationals policy will be argued through that process," she said.

Member for Oxley Melinda Pavey said The Nationals' had a responsibility to explore its options on nuclear power.

"We have a responsibility to the people of NSW, given 40 per cent of the world's uranium is in Australia, to explore these type of opportunities," she said.

"We know there would be billions in royalties to NSW for our schools hospitals and roads from allowing uranium mining to take place."

Labor's climate change and energy spokesperson and shadow minister for the North Coast Adam Searle said the party will maintain a ban on uranium exploration, extraction and export.

"A Labor government will not introduce nuclear power in NSW," Mr Searle said.

"Nuclear is the most expensive form of power and its waste is a disaster for the environment.

"Regional and coastal communities now face the grim prospect of becoming a nuclear power plant wasteland, as a result of Mr Barilaro leading this government by the nose."

But the deputy premier's stance is not new.

He has been raising the nuclear power issue for at least the last three years.

Hansard records show that the deputy leader called for a "mature debate" on the topic.

"The bigger picture in relation to energy is not just nuclear energy but the cost of living for households," Mr Barilaro said in parliament.

"A mature society needs to have mature conversations. To tackle the big issues we need to look to the big solutions.

"This is about having a conversation not in this place but within the community.

"We should seek engagement with the community in order to have a broader conversation around energy," he said.

"This is about having the guts to have the conversation on many issues - for example, about nuclear energy as part of the energy debate.

"We as leaders do not have all the answers. We have to take the fearmongering and mistruth out of the energy debate and look at the science.

"All I am asking is that we have the conversation about the options for energy generation. There is room for renewables and for coal."

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