Emergency services were called to Ocean Drive at 4.15pm to find three cars and a truck had been involved in a crash.

Ambulance NSW crews treated a 45-year-old woman for minor lacerations to her arm.

A 56-year-old person was assessed on scene and had no obvious injuries, while a 46-year-old man was treated for cuts to his arms.

A 41-year-old woman with more serious injuries was released from her vehicle and transported to Port Macquarie Base Hospital.

She is in a stable condition, a NSW ambulance spokesperson said.

Traffic was affected in both directions on Ocean Drive and motorists are being urged to exercise caution or choose alternative routes.

Fire and Rescue NSW were on scene and NSW Police will commence an investigation into the cause of the accident.

Meanwhile, a car crash on the Pacific Highway at Telegraph Point at 5pm closed the highway in both directions for a short period of time.

Emergency services also attended that accident before it was cleared within the hour.