The campus is operational with staff members launching their working week at the campus off Major Innes Road.

The relocation to the new campus started on Friday and continued over the weekend.

Charles Sturt University Port Macquarie head of campus Professor Heather Cavanagh said the coordination during weekend move was fabulous.

"We've had the usual few teething problems, but in the main, it has gone remarkable smoothly," she said about the relocation.

Students return from their mid-session break on April 26.

The multi-level stage one building is set around a landscaped central courtyard.

Stage one includes flexible teaching spaces, administrative areas, learning commons and library, student central, specialised simulation space and Indigenous courtyard with an amphitheatre.

The development of the campus cost $47 million with the federal government funding $20 million and CSU providing the remainder.